
US-Iran talks collapsed in Islamabad on April 11-12 after 47 years of no direct negotiations. Vice President JD Vance led the US delegation seeking nuclear rollback and Strait of Hormuz control. Iran's speaker Mohammad Bagher Ghalibaf demanded comprehensive ceasefire, sanctions relief, asset unfreezing, and regional recognition. Deep trust deficit from past JCPOA abrogation prevented agreement. Both sides blamed each other, with escalation risks increasing.