
US-Iran negotiations in Islamabad ended without agreement after 12 hours of talks on Sunday. The discussions, the highest-level direct engagement since 1979, centered on Iran's nuclear programme. Six key disagreements remain: uranium enrichment, facility dismantling, stockpile removal, regional security framework, terrorist funding, and Strait of Hormuz access. A two-week ceasefire provides limited time. Pakistan maintains its mediation role. US Vice President JD Vance presented a final proposal, leaving the door slightly open.